An effective pet supplement demands care and thought. Guided by global research and clinical trials, our formulas target the cellular and joint health challenges pets face with age — like no other.

Heart Health

Mitochondrial decline is a key factor in heart disease. A 2017 study, “Short-term administration of Nicotinamide Mononucleotide preserves cardiac mitochondrial homeostasis and prevents heart failure”, found that NMN supported mitochondrial function and helped protect against heart failure in mice. While the work was conducted in rodents, the mechanisms involved — mitochondrial stability and energy production — are highly relevant to canine heart health.

Vascular Function

Vascular aging is linked to stiffness, oxidative stress, and poor circulation. In a 2016 paper published in Aging Cell, “Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice”, NMN was shown to restore vascular elasticity and reduce oxidative stress. A separate 2020 toxicity study also observed lower blood lipid levels, including total cholesterol and triglycerides, in animals supplemented with NMN — both of which contribute to healthier cardiovascular function.

Metabolic Support & Diabetes

Metabolic decline is a hallmark of aging in both humans and pets. A 2012 study, “Nicotinamide mononucleotide, a key NAD⁺ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice”, reported that NMN improved insulin sensitivity and glucose tolerance. These findings suggest NMN could have a role in supporting pets with age- or diet-related glucose regulation challenges.

Cognitive Function & Aging

Oxidative stress and mitochondrial dysfunction are also central to age-related cognitive decline. In a 2017 study, “Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease”, NMN supplementation improved cognition and reduced amyloid plaque burden in mice. This, combined with evidence from the 2018 review “Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence” (Rajman, Chwalek & Sinclair), highlights NMN’s broader role in maintaining NAD⁺ levels and potentially slowing aspects of neurological aging — making it an intriguing candidate for supporting pets with cognitive decline.

• A study feeding GLM-supplemented diet for 45 days to dogs with arthritis showed clinical improvements in signs such as pain, swelling, and crepitus versus baseline.
  
• In a blinded placebo-controlled trial (101 dogs) using a combination of GLM + krill oil extracts (EAB-277) vs NSAIDs/other extracts, GLM combination delivered significant pain relief in dogs with hip osteoarthritis.

• Trials using glucosamine in canine osteoarthritis show measurable improvements in comfort, reduced lameness, especially in mild-to-moderate cases.

• Other studies show slower progression of cartilage damage / symptoms when glucosamine + chondroitin are used as adjuncts to diet / other therapies.

• Studies in dogs post-joint injury or surgery show that HA supplementation supports improved biomarkers of cartilage metabolism and helps recovery.

• Specifically, dogs with knee surgery (cranial cruciate ligament rupture, TTA), oral HA improved biomarkers of osteoarthritis over 10 weeks (increases in HA, decreases in inflammation markers).

• Omega-3 fatty acids in fish oil have been shown to reduce joint pain and improve mobility in dogs with osteoarthritis, particularly when combined with other joint support agents.
• In dogs with osteoarthritis, fish oil improved weight bearing and reduced inflammation per owner assessments and objective gait analysis.

• Animal nutrition research and guideline-reviews consistently show that manganese deficiency impairs cartilage health and slows soft-tissue repair, while balanced manganese intake helps support joint resilience, metabolic function, and antioxidant defense.

• Studies in dogs show that Vitamin E, especially in combination with other antioxidants, helps reduce biomarkers of oxidative stress in aging or joint-stressed animals.
• In general biology and veterinary nutrition literature: vitamin C improves oxidative stress markers in aged animals, helps support immune resilience.
• Diets enriched with vitamins E, C, and β-carotene reduced markers of oxidative damage. Animals fed these diets showed increased antioxidant capacity and less cellular degradation.